An international framework convention protocol approach for nanotechnology is an intriguing notion and one that would appear to make good sense. This Comment on Profs. Kenneth Abbott, Gary Marchant, and Douglas Sylvester's proposal, as set forth in their excellent article entitled A Framework Convention for Nanotechnology?, is offered more to spark further thought than as a response to the question they pose. As discussed more below, given the inherent appeal of the proposal, the real question may be not whether, but when a framework convention approach should be pursued in earnest, and how best to initiate the process to ensure its success.