The express mission of the National Wildlife Refuge System “is to administer a national network of lands and waters for conservation, management, and where appropriate, restoration of the fish, wildlife and plant resources and their habitats within the United States.” But the establishment of individual refuges has not always focused on achieving a genuine network of conservation lands. Taking the Everglades Headwaters National Wildlife Refuge as a model, this Article explores how the landscape-level approach can help the Refuge System more fully realize its conservation mission and restoration potential.